Bruce E Clurman Selected Research

Cyclin E

1/2019	Insertional mutagenesis using the Sleeping Beauty transposon system identifies drivers of erythroleukemia in mice.
5/2013	Essential role for Cdk2 inhibitory phosphorylation during replication stress revealed by a human Cdk2 knockin mutation.
9/2011	Hypoxia-inducible factor 1 is activated by dysregulated cyclin E during mammary epithelial morphogenesis.
6/2008	Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo.
7/2005	Ras activity regulates cyclin E degradation by the Fbw7 pathway.
7/2005	A mouse model for cyclin E-dependent genetic instability and tumorigenesis.
4/2005	Cyclin E in normal and neoplastic cell cycles.
10/2004	A nucleolar isoform of the Fbw7 ubiquitin ligase regulates c-Myc and cell size.
6/2004	The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation.
10/2002	p53 and p21 form an inducible barrier that protects cells against cyclin E-cdk2 deregulation.

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Bruce E Clurman Research Topics

Disease

26	Neoplasms (Cancer) 01/2022 - 08/2002
12	Carcinogenesis 01/2022 - 06/2004
3	Lymphoma (Lymphomas) 08/2017 - 07/2007
2	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 01/2019 - 08/2007
2	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 01/2019 - 08/2007
1	Colorectal Neoplasms (Colorectal Cancer) 01/2022
1	Myeloid Leukemia (Leukemia, Myelocytic) 01/2021
1	Squamous Cell Carcinoma of Head and Neck 11/2020
1	Merkel Cell Carcinoma 01/2019
1	T-Cell Lymphoma (Lymphoma, T Cell) 08/2017
1	Breast Neoplasms (Breast Cancer) 12/2014
1	Genomic Instability 05/2013
1	Disease Progression 06/2012
1	Hypoxia (Hypoxemia) 09/2011
1	Anemia 06/2008
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 08/2007
1	Hyperplasia 08/2006
1	Chromosome Aberrations (Chromosome Abnormalities) 01/2006
1	Chromosome Breakage 07/2005
1	Lung Neoplasms (Lung Cancer) 07/2005
1	Retinoblastoma (Glioblastoma, Retinal) 12/2004
1	Werner Syndrome (Werner's Syndrome) 07/2003

Drug/Important Bio-Agent (IBA)

10	Proteins (Proteins, Gene)FDA Link 01/2021 - 07/2003
10	Cyclin EIBA 01/2019 - 10/2002
9	UbiquitinIBA 01/2022 - 10/2004
9	Ligases (Synthetase)IBA 01/2022 - 10/2004
4	CyclinsIBA 01/2019 - 10/2002
4	SKP Cullin F-Box Protein LigasesIBA 10/2014 - 06/2004
3	Oncogene Proteins (Oncogene Protein)IBA 11/2020 - 01/2018
3	Phosphotransferases (Kinase)IBA 11/2020 - 07/2005
3	MicroRNAs (MicroRNA)IBA 08/2017 - 01/2006
2	Notch ReceptorsIBA 01/2013 - 08/2007
2	Cyclin-Dependent Kinases (cdk Proteins)IBA 10/2008 - 08/2002
1	Arginine (L-Arginine)FDA Link 01/2022
1	Threonine (L-Threonine)FDA Link 01/2022
1	RNA (Ribonucleic Acid)IBA 01/2022
1	TubulinIBA 01/2021
1	adavosertibIBA 11/2020
1	Tumor Viral Antigens (Large T Antigen)IBA 01/2019
1	Proto-Oncogene Proteins c-etsIBA 01/2019
1	Neoplasm Antigens (Tumor Antigens)IBA 01/2019
1	TransposasesIBA 01/2019
1	F-Box-WD Repeat-Containing Protein 7IBA 01/2018
1	Biomarkers (Surrogate Marker)IBA 12/2014
1	Lapatinib (GW572016)FDA Link 12/2014
1	Calcibiotic Root Canal SealerIBA 06/2012
1	EnzymesIBA 10/2008
1	Indicators and Reagents (Reagents)IBA 12/2007
1	Transcription Factors (Transcription Factor)IBA 12/2007
1	Cyclin-Dependent Kinase Inhibitor p27IBA 12/2007
1	Gamma Secretase Inhibitors and ModulatorsIBA 08/2007
1	imidazole mustard (BIC)IBA 01/2006
1	Protein Isoforms (Isoforms)IBA 10/2005
1	Tumor Suppressor Proteins (Proteins, Tumor Suppressor)IBA 12/2004
1	Proteasome Endopeptidase Complex (Proteasome)IBA 06/2004
1	Glycogen Synthase Kinase 3IBA 06/2004
1	RecQ HelicasesIBA 07/2003
1	Tumor Suppressor Protein p14ARF (p14ARF)IBA 10/2002
1	Cyclin DIBA 10/2002
1	Retinoblastoma ProteinIBA 10/2002

Therapy/Procedure

9	Therapeutics 01/2022 - 08/2003
1	Drug Therapy (Chemotherapy) 01/2021
1	Cell Transplantation 08/2007